Amy Schumer’s New Chapter — Health, Healing & Homecomings

Amy Schumer shares her health journey and recent moves — from confronting Cushing’s syndrome to relocating her family. Discover where she’s living now, how she’s advocating for women’s health, and what this means for access to care.

Amy Schumer’s Health Journey From Endometriosis to Cushing’s Syndrome & Transformative Weight Loss

Amy Schumer — known for her fearless humor and candid storytelling — recently opened up about a serious health scare that took many by surprise. In 2024 she was diagnosed with Cushing's syndrome, a hormonal disorder caused by excessive cortisol levels. In late 2025 she clarified she lost around 50 pounds — not for cosmetic reasons — but as a critical step in managing the disease and safeguarding her life.

Amy admitted that her health became a concern after social media users began commenting on what they perceived as a “puffier,” rounder face. These comments, albeit unsolicited and often cruel, triggered suspicion. Eventually, after extensive testing, she publicly announced:

“I learned I had this condition … I’m starring in a movie — and there’s a camera right in my face,” she said, reflecting on the harsh spotlight balanced against her diagnosis.

In doing so, Amy used her platform to shine a light on a condition many know little about — hoping to destigmatize body changes and encourage self-advocacy. As she explained, this journey pushed her to champion greater understanding for women’s health and body acceptance.

Amy’s health story hasn’t been simple. Back in 2022, she revealed she had been struggling with Endometriosis — a condition in which tissue similar to the uterine lining grows elsewhere in the body, often causing intense pain and a cascade of hormonal challenges. She also underwent the removal of her uterus and appendix due to complications related to endometriosis.

But the most dramatic shift came with her Cushing’s syndrome diagnosis. According to reliable medical sources, Cushing’s is caused by prolonged exposure to high cortisol levels — whether produced by the body or introduced through medication such as steroid injections. In Amy’s case, she believes steroid injections she received for scar treatment may have triggered the disorder.

Such a diagnosis is not rare in the sense that many suffer from hormone-related conditions, but it remains largely misunderstood by the general public — making her openness all the more important.

Cushing’s syndrome treatment depends on the root cause. If cortisol overproduction stems from a tumor (in the adrenal or pituitary gland), standard care may involve surgery, radiation, or medication to suppress cortisol. However, in cases triggered by external steroid injections — like the one Amy described — removing the source and tapering off the steroid is often the primary approach.

Thankfully, medical experts generally regard steroid-induced Cushing’s as reversible if managed early. Many patients see symptoms — such as "moon face," weight gain, and fat redistribution — gradually subside over months once the steroids are stopped and cortisol levels normalize.

That said, recovery is not always smooth. Reversal can involve physical challenges — fatigue, muscle weakness, and metabolic changes — along with the psychological toll of dramatic body changes. For someone in the public eye like Amy, there’s the added scrutiny, which can complicate self-image and mental health.

Amy has spoken candidly about feeling “reborn” after her diagnosis — grateful for her resources, medical care, and the support system that allowed her to get treatment early. But she’s also careful to recognize that many people with similar conditions don’t have the means she does:

“I feel so privileged to have the resources available to address my health issues... we never know what is going on with someone.”

For countless others, life-saving diagnostics, specialist consultations, hormone tests, and ongoing treatment remain financially out of reach. Amy’s transparency exposes an uncomfortable truth: good health is often tied to access and privilege — not just medical need.

By sharing her story, Amy not only reclaims her body and health, but also draws attention to systemic inequities in care. That, arguably, may be one of the most powerful contributions she can make.